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KMID : 1098420110190040251
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Korean Journal of Medicinal Crop Science
2011 Volume.19 No. 4 p.251 ~ p.256
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Isolation of Flavonol Glycoside Related to Antioxidant Activity from Hippophae rhamnoides Leaves
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Lee Ji-Won
Park Ju-Hee
Kim Ju-Sung
Choi Eun-Young
Han Sang-No
Seong Eun-Soo
Yu Chang-Yeon
Kwon Yong-Soo
Kim Myong-Jo
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Abstract
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The leaves of Hippophae rhamnoides were extracted with methanol and then further fractioned with hexane, ethyl acetate, butanol and water in order to investigate biological activity. Two flavonol glycosides were isolated and identified from ethyl acetate soluble fraction, which showed the strongest antioxidant activity ( = 4.33 ). Isolated two compounds have shown strong free radical scavenging activity. Especially, quercetin 3-O-glucoside ( = 2.60 ) was more active than -tocopherol ( = 4.67 ). Total phenol and flavonoid contents were the highest to 4.17 and 1.14 mg/ml in the ethyl acetate soluble fraction. In addition, ethyl acetate soluble fraction was shown to the strongest -glucosidase inhibitory activity ( = 137.88 ) among the fractions. The results suggest that leaves of H. rhamnoides could be a potential source of natural antioxidant.
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KEYWORD
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Hippophae rhamnoides, Flavonol Glycoside, DPPH Free Radical Activity, -Glucosidase Inhibitory Activity
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